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creb inhibitor kg501  (MedChemExpress)


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    MedChemExpress creb inhibitor kg501
    Creb Inhibitor Kg501, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 32 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/creb+inhibitor+kg501/KG-501/pm41276512-600-8-13
    Average 95 stars, based on 32 article reviews
    creb inhibitor kg501 - by Bioz Stars, 2026-09
    95/100 stars

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    Saline:

    Article Title: Tanshinone IIA improves contextual fear- and anxiety-like behaviors in mice via the CREB/BDNF/TrkB signaling pathway.
    Article Snippet: Funding information Major International Cooperation in Shaanxi, Grant/Award Number: 2017KW-ZD-01; National Natural Science Foundation of China, Grant/Award Numbers: 82003734, 82071474, 32000715; Youth Talent Promotion Program of Shaanxi Association for Science and Technology, Grant/Award Number: 20210306 Abstract Posttraumatic stress disorder (PTSD) is one of the most common psychiatric diseases, which is characterized by the typical symptoms such as re-experience, avoidance, and hyperarousal.. However, there are few drugs for PTSD treatment.. In this study, conditioned fear and single-prolonged stress were employed to establish PTSD mouse model, and we investigated the effects of Tanshinone IIA (TanIIA), a natural product isolated from traditional Chinese herbal Salvia miltiorrhiza, as well as the underlying mechanisms in mice.

    Concentration Assay:

    Article Title: Tanshinone IIA improves contextual fear- and anxiety-like behaviors in mice via the CREB/BDNF/TrkB signaling pathway.
    Article Snippet: Funding information Major International Cooperation in Shaanxi, Grant/Award Number: 2017KW-ZD-01; National Natural Science Foundation of China, Grant/Award Numbers: 82003734, 82071474, 32000715; Youth Talent Promotion Program of Shaanxi Association for Science and Technology, Grant/Award Number: 20210306 Abstract Posttraumatic stress disorder (PTSD) is one of the most common psychiatric diseases, which is characterized by the typical symptoms such as re-experience, avoidance, and hyperarousal.. However, there are few drugs for PTSD treatment.. In this study, conditioned fear and single-prolonged stress were employed to establish PTSD mouse model, and we investigated the effects of Tanshinone IIA (TanIIA), a natural product isolated from traditional Chinese herbal Salvia miltiorrhiza, as well as the underlying mechanisms in mice.

    Functional Assay:

    Article Title: Mechano-bioactive hydrogel bioelectronics for mechanical-electrical-bioenergetic conversion and glia-modulating neural regeneration.
    Article Snippet: .. To assess the functional contribution of Calcium-CREB signaling, CREB inhibitor KG501 (cat. #HY-103299, MedChemExpress, USA) was applied in hydrogel-embedded RSC96 cell lines and CTX TNA2 cell lines. ..

    Article Title: Mechano-bioactive hydrogel bioelectronics for mechanical-electrical-bioenergetic conversion and glia-modulating neural regeneration
    Article Snippet: .. To assess the functional contribution of Calcium-CREB signaling, CREB inhibitor KG501 (cat. #HY-103299, MedChemExpress, USA) was applied in hydrogel-embedded RSC96 cell lines and CTX TNA2 cell lines. ..

    Incubation:

    Article Title: Photobiomodulation therapy at 632 nm wavelength ameliorates intrauterine adhesion via activation of cAMP/PKA/CREB pathway.
    Article Snippet: Intrauterine adhesion (IUA), or Asherman's syndrome, has the pathological characterization of a completely or partially blocked uterine cavity caused by endometrial fibrosis, mainly resulting from endometrial injury or infection.1 IUA is the most common cause of secondary infertility in females and can lead to other problems in the reproductive system, such as hypomenorrhea, amenorrhea, and recurrent abortion.1 Therefore, uterine cavity Received: 13 February 2023 | Revised: 3 May 2023 | Accepted: 4 May 2023 DOI: 10.1111/php.13813



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    Blockade effects of the adenylyl cyclase inhibitor DDA, PKA activation inhibitor H-89, p38 activation inhibitor SB203580, and CREB activation inhibitor <t>KG501</t> on cynandione-A-induced spinal mechanical antiallodynia and mRNA expression of IL-10 and the β-endorphin precursor proopiomelanocortin (POMC (C) ) in the spinal cords of neuropathic rats induced by spinal nerve ligation (A–C) and cultured primary microglial cells originated from 1-day-old neonatal rats (D, E) . Neuropathic rats received intrathecally the vehicle or DDA, H-89, SB203580 and KG501 30 min followed by cynandione A. The spinal cords and cultured microglial cells were obtained 1 h after the last intrathecal injection or 2 h after incubation to detect IL-10 and POMC gene expression by using qRT-PCR. Data are shown as means ± SEM ( n = 6 per group in neuropathic rats or n = 3 per group with two independent repeats in cultured cells). *, # p < 0.05 compared with the control and cynandione A treatment groups, respectively, analyzed by one-way or two-way ANOVA followed by the post-hoc Student-Newman-Keuls test.
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    Blockade effects of the adenylyl cyclase inhibitor DDA, PKA activation inhibitor H-89, p38 activation inhibitor SB203580, and CREB activation inhibitor <t>KG501</t> on cynandione-A-induced spinal mechanical antiallodynia and mRNA expression of IL-10 and the β-endorphin precursor proopiomelanocortin (POMC (C) ) in the spinal cords of neuropathic rats induced by spinal nerve ligation (A–C) and cultured primary microglial cells originated from 1-day-old neonatal rats (D, E) . Neuropathic rats received intrathecally the vehicle or DDA, H-89, SB203580 and KG501 30 min followed by cynandione A. The spinal cords and cultured microglial cells were obtained 1 h after the last intrathecal injection or 2 h after incubation to detect IL-10 and POMC gene expression by using qRT-PCR. Data are shown as means ± SEM ( n = 6 per group in neuropathic rats or n = 3 per group with two independent repeats in cultured cells). *, # p < 0.05 compared with the control and cynandione A treatment groups, respectively, analyzed by one-way or two-way ANOVA followed by the post-hoc Student-Newman-Keuls test.
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    Blockade effects of the adenylyl cyclase inhibitor DDA, PKA activation inhibitor H-89, p38 activation inhibitor SB203580, and CREB activation inhibitor KG501 on cynandione-A-induced spinal mechanical antiallodynia and mRNA expression of IL-10 and the β-endorphin precursor proopiomelanocortin (POMC (C) ) in the spinal cords of neuropathic rats induced by spinal nerve ligation (A–C) and cultured primary microglial cells originated from 1-day-old neonatal rats (D, E) . Neuropathic rats received intrathecally the vehicle or DDA, H-89, SB203580 and KG501 30 min followed by cynandione A. The spinal cords and cultured microglial cells were obtained 1 h after the last intrathecal injection or 2 h after incubation to detect IL-10 and POMC gene expression by using qRT-PCR. Data are shown as means ± SEM ( n = 6 per group in neuropathic rats or n = 3 per group with two independent repeats in cultured cells). *, # p < 0.05 compared with the control and cynandione A treatment groups, respectively, analyzed by one-way or two-way ANOVA followed by the post-hoc Student-Newman-Keuls test.

    Journal: Frontiers in Pharmacology

    Article Title: Cynandione A Alleviates Neuropathic Pain Through α7-nAChR-Dependent IL-10/β-Endorphin Signaling Complexes

    doi: 10.3389/fphar.2020.614450

    Figure Lengend Snippet: Blockade effects of the adenylyl cyclase inhibitor DDA, PKA activation inhibitor H-89, p38 activation inhibitor SB203580, and CREB activation inhibitor KG501 on cynandione-A-induced spinal mechanical antiallodynia and mRNA expression of IL-10 and the β-endorphin precursor proopiomelanocortin (POMC (C) ) in the spinal cords of neuropathic rats induced by spinal nerve ligation (A–C) and cultured primary microglial cells originated from 1-day-old neonatal rats (D, E) . Neuropathic rats received intrathecally the vehicle or DDA, H-89, SB203580 and KG501 30 min followed by cynandione A. The spinal cords and cultured microglial cells were obtained 1 h after the last intrathecal injection or 2 h after incubation to detect IL-10 and POMC gene expression by using qRT-PCR. Data are shown as means ± SEM ( n = 6 per group in neuropathic rats or n = 3 per group with two independent repeats in cultured cells). *, # p < 0.05 compared with the control and cynandione A treatment groups, respectively, analyzed by one-way or two-way ANOVA followed by the post-hoc Student-Newman-Keuls test.

    Article Snippet: The adenylate cyclase inhibitor 2,5-dideoxyadenosine (DDA) and PKA activation inhibitor H-89 were obtained from Santa Cruz Biotechnologies (Santa Cruz, CA, United States), while the p38 activation inhibitor SB203580, CREB activation inhibitor KG501, and STAT3 activation inhibitor NSC74859 were purchased from Selleck Chemicals (Houston, TX, United States), Sigma-Aldrich (St. Louis, MO, United States), and Medchem Express (Boston, United States), respectively.

    Techniques: Activation Assay, Expressing, Ligation, Cell Culture, Injection, Incubation, Gene Expression, Quantitative RT-PCR, Control

    Blockade effects of the adenylyl cyclase inhibitor DDA, PKA activation inhibitor H-89, p38 activation inhibitor SB203580, and CREB activation inhibitor KG501 on cynandione-A-induced spinal mechanical antiallodynia and mRNA expression of IL-10 and the β-endorphin precursor proopiomelanocortin (POMC (C) ) in the spinal cords of neuropathic rats induced by spinal nerve ligation (A–C) and cultured primary microglial cells originated from 1-day-old neonatal rats (D, E) . Neuropathic rats received intrathecally the vehicle or DDA, H-89, SB203580 and KG501 30 min followed by cynandione A. The spinal cords and cultured microglial cells were obtained 1 h after the last intrathecal injection or 2 h after incubation to detect IL-10 and POMC gene expression by using qRT-PCR. Data are shown as means ± SEM ( n = 6 per group in neuropathic rats or n = 3 per group with two independent repeats in cultured cells). *, # p < 0.05 compared with the control and cynandione A treatment groups, respectively, analyzed by one-way or two-way ANOVA followed by the post-hoc Student-Newman-Keuls test.

    Journal: Frontiers in Pharmacology

    Article Title: Cynandione A Alleviates Neuropathic Pain Through α7-nAChR-Dependent IL-10/β-Endorphin Signaling Complexes

    doi: 10.3389/fphar.2020.614450

    Figure Lengend Snippet: Blockade effects of the adenylyl cyclase inhibitor DDA, PKA activation inhibitor H-89, p38 activation inhibitor SB203580, and CREB activation inhibitor KG501 on cynandione-A-induced spinal mechanical antiallodynia and mRNA expression of IL-10 and the β-endorphin precursor proopiomelanocortin (POMC (C) ) in the spinal cords of neuropathic rats induced by spinal nerve ligation (A–C) and cultured primary microglial cells originated from 1-day-old neonatal rats (D, E) . Neuropathic rats received intrathecally the vehicle or DDA, H-89, SB203580 and KG501 30 min followed by cynandione A. The spinal cords and cultured microglial cells were obtained 1 h after the last intrathecal injection or 2 h after incubation to detect IL-10 and POMC gene expression by using qRT-PCR. Data are shown as means ± SEM ( n = 6 per group in neuropathic rats or n = 3 per group with two independent repeats in cultured cells). *, # p < 0.05 compared with the control and cynandione A treatment groups, respectively, analyzed by one-way or two-way ANOVA followed by the post-hoc Student-Newman-Keuls test.

    Article Snippet: The adenylate cyclase inhibitor 2,5-dideoxyadenosine (DDA) and PKA activation inhibitor H-89 were obtained from Santa Cruz Biotechnologies (Santa Cruz, CA, United States), while the p38 activation inhibitor SB203580, CREB activation inhibitor KG501, and STAT3 activation inhibitor NSC74859 were purchased from Selleck Chemicals (Houston, TX, United States), Sigma-Aldrich (St. Louis, MO, United States), and Medchem Express (Boston, United States), respectively.

    Techniques: Activation Assay, Expressing, Ligation, Cell Culture, Injection, Incubation, Gene Expression, Quantitative RT-PCR, Control

    Blockade effects of the adenylyl cyclase inhibitor DDA, PKA activation inhibitor H-89, p38 activation inhibitor SB203580, and CREB activation inhibitor KG501 on cynandione-A-induced spinal mechanical antiallodynia and mRNA expression of IL-10 and the β-endorphin precursor proopiomelanocortin (POMC (C) ) in the spinal cords of neuropathic rats induced by spinal nerve ligation (A–C) and cultured primary microglial cells originated from 1-day-old neonatal rats (D, E) . Neuropathic rats received intrathecally the vehicle or DDA, H-89, SB203580 and KG501 30 min followed by cynandione A. The spinal cords and cultured microglial cells were obtained 1 h after the last intrathecal injection or 2 h after incubation to detect IL-10 and POMC gene expression by using qRT-PCR. Data are shown as means ± SEM ( n = 6 per group in neuropathic rats or n = 3 per group with two independent repeats in cultured cells). *, # p < 0.05 compared with the control and cynandione A treatment groups, respectively, analyzed by one-way or two-way ANOVA followed by the post-hoc Student-Newman-Keuls test.

    Journal: Frontiers in Pharmacology

    Article Title: Cynandione A Alleviates Neuropathic Pain Through α7-nAChR-Dependent IL-10/β-Endorphin Signaling Complexes

    doi: 10.3389/fphar.2020.614450

    Figure Lengend Snippet: Blockade effects of the adenylyl cyclase inhibitor DDA, PKA activation inhibitor H-89, p38 activation inhibitor SB203580, and CREB activation inhibitor KG501 on cynandione-A-induced spinal mechanical antiallodynia and mRNA expression of IL-10 and the β-endorphin precursor proopiomelanocortin (POMC (C) ) in the spinal cords of neuropathic rats induced by spinal nerve ligation (A–C) and cultured primary microglial cells originated from 1-day-old neonatal rats (D, E) . Neuropathic rats received intrathecally the vehicle or DDA, H-89, SB203580 and KG501 30 min followed by cynandione A. The spinal cords and cultured microglial cells were obtained 1 h after the last intrathecal injection or 2 h after incubation to detect IL-10 and POMC gene expression by using qRT-PCR. Data are shown as means ± SEM ( n = 6 per group in neuropathic rats or n = 3 per group with two independent repeats in cultured cells). *, # p < 0.05 compared with the control and cynandione A treatment groups, respectively, analyzed by one-way or two-way ANOVA followed by the post-hoc Student-Newman-Keuls test.

    Article Snippet: The adenylate cyclase inhibitor 2,5-dideoxyadenosine (DDA) and PKA activation inhibitor H-89 were obtained from Santa Cruz Biotechnologies (Santa Cruz, CA, United States), while the p38 activation inhibitor SB203580, CREB activation inhibitor KG501, and STAT3 activation inhibitor NSC74859 were purchased from Selleck Chemicals (Houston, TX, United States), Sigma-Aldrich (St. Louis, MO, United States), and Medchem Express (Boston, United States), respectively.

    Techniques: Activation Assay, Expressing, Ligation, Cell Culture, Injection, Incubation, Quantitative RT-PCR, Control